Pseudomonas aeruginosa causes a variety of infections including bacteremia, urinary tract infections, hospital-acquired pneumonia and ventilator-associated pneumonia (VAP). The rapidity with which patients succumb to severe pseudomonal infections is disturbing as up to 50% of patients with P. aeruginosa bacteremia die within the first 24–72 hours of diagnosis.  In 2007, P. aeruginosa caused 16% of VAPs, 10% of catheter associated urinary tract infections, 6% of surgical site infections and 3% of central line–associated bloodstream infections in the US.