Klebsiella pneumoniae is a non-motile bacterium found in the normal flora of the mouth, skin and intestines. This organism is often cultured from hospitalized patients’ sputum or respiratory secretions, wounds and urine. Multidrug-resistant Klebsiella pneumoniae is an emerging phenomenon and the most common sites of infections were blood (52%), followed by respiratory (30%), and urine (10%). Respiratory infections have been shown to be associated with high rates of treatment failure. However, combination therapy is recommended for the treatment of KPC. Treatment failure rates for the most common combinations of polymycin is approximately 30%.